Father Mark Boyer served the parish from its inception in 2004 to 2011.
In July 2011, Monsignor Thomas Reidy was assigned as pastor to St. Francis of Assisi. He is also pastor of St. Elizabeth Ann Seton Parish, Springfield. At that time, Father Paul Anthony Suresh Samala served as associate pastor. Sharing sacramental duties starting in 2014 was Father Michael McDevitt.
In September 2017, newly-ordained priest Father Colby Elbert was named associate pastor and Father McDevitt retired as our priest in residence.
In July 2021, Monsignor Thomas Reidy was assigned as the full-time pastor for St. Francis of Assisi. Father Colby Elbert was reassigned as Parochial Administrator of St. Francis Xavier Parish in Sikeston, Missouri.